The b5media Blog Network recently got an Akismet Enterprise License and is installing it for all their blogs. For people running dozens or even hundreds of blogs, I can’t imagine how much time Akismet spam protection saves for them and their writers. I’m biased, but I think it’s a very prescient move on their part.
Moderation can protect any blog but with spam ever rising you have to ask if all the time it takes to sift through so many comments is really worth it.
Update: A little more information about it at Blogging Pro and from the b5media blog.